{"id":112428,"date":"2022-07-26T22:13:00","date_gmt":"2022-07-26T19:13:00","guid":{"rendered":"https:\/\/life.karpat.in.ua\/?p=112428"},"modified":"2022-07-26T17:12:38","modified_gmt":"2022-07-26T14:12:38","slug":"kifejlesztettek-egy-ujfajta-fajdalomcsillapitot-ami-nem-okoz-fuggoseget","status":"publish","type":"post","link":"https:\/\/life.karpat.in.ua\/?p=112428&lang=hu","title":{"rendered":"Kifejlesztettek egy \u00fajfajta f\u00e1jdalomcsillap\u00edt\u00f3t, ami nem okoz f\u00fcgg\u0151s\u00e9get"},"content":{"rendered":"\n

Kutat\u00f3k egy \u00faj, f\u00fcgg\u0151s\u00e9get nem okoz\u00f3 f\u00e1jdalomcsillap\u00edt\u00f3t fedeztek fel, amely komoly alternat\u00edv\u00e1ja lehet az olyan opioid gy\u00f3gyszerhat\u00f3anyagoknak, mint a morfium \u00e9s az oxikodon \u2013 der\u00fcl ki a Nature Communications c\u00edm\u0171 foly\u00f3iratban nemr\u00e9g megjelent tanulm\u00e1nyb\u00f3l.<\/strong><\/p>\n\n\n

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\"\"<\/figure>\n<\/div>\n\n\n

Az \u00edg\u00e9retes vegy\u00fclet neve benziloxi-ciklopentiladenozin (r\u00f6viden: BnOCPA). A hat\u00f3anyagot eddig f\u0151k\u00e9nt \u00e1llati szervek eset\u00e9ben \u2013 b\u00e9kasz\u00edven, patk\u00e1nyagyon, illetve emberi sejteken \u2013 tesztelte egy nemzetk\u00f6zi kutat\u00f3csoport. Szerint\u00fck a BnOCPA nem okoz f\u00fcgg\u0151s\u00e9get, a hat\u00e1sa pedig \u00edgy is l\u00e1tv\u00e1nyos.<\/p>\n\n\n\n

Az IFLScience szerint a hasonl\u00f3 szerek ismert mell\u00e9khat\u00e1sai k\u00f6z\u00e9 tartozik t\u00f6bbek k\u00f6zt a szed\u00e1ci\u00f3, \u00e9s a bradycardia is, ami a lelassult sz\u00edvver\u00e9st jelenti. Bizonyos k\u00e9sz\u00edtm\u00e9nyek r\u00e1ad\u00e1sul t\u00faladagol\u00e1shoz is vezethetnek, ez\u00e9rt nagyon fontos lenne \u00faj, biztons\u00e1gos f\u00e1jdalomcsillap\u00edt\u00f3k kifejleszt\u00e9se.<\/p>\n\n\n\n

A port\u00e1l szerint sz\u00e1mos hat\u00f3anyag \u00fagy fejti ki hat\u00e1s\u00e1t, hogy k\u00f6lcs\u00f6nhat\u00e1sba l\u00e9p a sejt felsz\u00edn\u00e9n l\u00e9v\u0151 feh\u00e9rj\u00e9kkel, amik aktiv\u00e1lj\u00e1k a G-feh\u00e9rj\u00e9knek nevezett adapter molekul\u00e1kat. Bizonyos G-feh\u00e9rj\u00e9k aktiv\u00e1l\u00e1sa azonban m\u00e1s sejthat\u00e1sokhoz is vezethet. A BnOCPA el\u0151nye abban rejlik a kutat\u00f3k szerint, hogy csak egyf\u00e9le G-feh\u00e9rj\u00e9t aktiv\u00e1l, \u00edgy a lehets\u00e9ges mell\u00e9khat\u00e1sok sz\u00e1ma is j\u00f3val kevesebb.<\/p>\n\n\n\n

A molekul\u00e1t m\u00e9g nem pr\u00f3b\u00e1lt\u00e1k ki \u00e9l\u0151 emberen, de az els\u0151 eredm\u00e9nyek is \u00edg\u00e9retesnek t\u0171nnek.<\/p>\n\n\n\n

A hivatalos adatok szerint csak az Egyes\u00fclt \u00c1llamokban \u00e9l\u0151k t\u00f6bb mint 20 sz\u00e1zal\u00e9ka szenved kr\u00f3nikus f\u00e1jdalomt\u00f3l.<\/p>\n\n\n\n

(hvg.hu)<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Kutat\u00f3k egy \u00faj, f\u00fcgg\u0151s\u00e9get nem okoz\u00f3 f\u00e1jdalomcsillap\u00edt\u00f3t fedeztek fel, amely komoly alternat\u00edv\u00e1ja lehet az olyan opioid gy\u00f3gyszerhat\u00f3anyagoknak, mint a morfium \u00e9s az oxikodon \u2013 der\u00fcl ki a Nature Communications c\u00edm\u0171 foly\u00f3iratban nemr\u00e9g megjelent tanulm\u00e1nyb\u00f3l.<\/p>\n","protected":false},"author":12,"featured_media":112429,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[41,594,596,592,598,39],"tags":[206128,206125,729,206127,206126],"class_list":["post-112428","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cikkek","category-egeszseg","category-erdekes","category-tarsadalom","category-tudomany","category-vilag","tag-bnocpa","tag-fajdalomcsillapito","tag-fuggoseg","tag-morfium","tag-oxikodon"],"_links":{"self":[{"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=\/wp\/v2\/posts\/112428","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=112428"}],"version-history":[{"count":1,"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=\/wp\/v2\/posts\/112428\/revisions"}],"predecessor-version":[{"id":112430,"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=\/wp\/v2\/posts\/112428\/revisions\/112430"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=\/wp\/v2\/media\/112429"}],"wp:attachment":[{"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=112428"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=112428"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=112428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}