{"id":66977,"date":"2021-08-10T22:04:00","date_gmt":"2021-08-10T19:04:00","guid":{"rendered":"http:\/\/life.karpat.in.ua\/?p=66977"},"modified":"2021-08-10T01:53:08","modified_gmt":"2021-08-09T22:53:08","slug":"minden-idok-legigeretesebb-rakgyogyszeret-fejlesztettek-ki-hamarosan-embereken-is-kiprobalhatjak","status":"publish","type":"post","link":"https:\/\/life.karpat.in.ua\/?p=66977&lang=hu","title":{"rendered":"Minden id\u0151k leg\u00edg\u00e9retesebb r\u00e1kgy\u00f3gyszer\u00e9t fejlesztett\u00e9k ki, hamarosan embereken is kipr\u00f3b\u00e1lhatj\u00e1k"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

R\u00e1gcs\u00e1l\u00f3kon elv\u00e9gzett k\u00eds\u00e9rletek alapj\u00e1n az \u00faj, h\u00e1rom gy\u00f3gyszerb\u0151l \u00e1ll\u00f3 kokt\u00e9l k\u00e9pes legy\u0151zni a hasny\u00e1lmirigyr\u00e1kot, \u00e9s ha minden j\u00f3l alakul, akkor embereken is hasonl\u00f3 hat\u00e1s \u00e9rhet\u0151 el a ter\u00e1pi\u00e1val.<\/strong><\/p>\n\n\n\n

A r\u00e1ksejtek az immunrendszer alapk\u00f6v\u00e9nek sz\u00e1m\u00edt\u00f3 T-sejteket t\u00e1madj\u00e1k meg, melyeket l\u00e9nyeg\u00e9ben k\u00e9pesek kikapcsolni, \u00edgy a szervezet k\u00e9ptelen felvenni a harcot a rosszindulat\u00fa sz\u00f6vetburj\u00e1nz\u00e1ssal, \u00e9s \u00e1tt\u00e9tek keletkeznek, az \u00e1ltaluk el\u0151id\u00e9zett sz\u00f6v\u0151dm\u00e9nyek v\u00e9g\u00fcl hal\u00e1lhoz vezetnek.<\/p>\n\n\n\n

L\u00e9teznek azonban \u00fagynevezett checkpoint inhib\u00edtorok, amelyek blokkolj\u00e1k a r\u00e1ksejtekben tal\u00e1lhat\u00f3 PD-L1 nev\u0171 feh\u00e9rj\u00e9t, illetve el\u0151fordulnak a szervezetben olyan immun T-sejtek is, mint p\u00e9ld\u00e1ul a PD-1-ek, amelyek hasonl\u00f3 hat\u00e1st tudnak kifejteni.<\/p>\n\n\n\n

Hasny\u00e1lmirigyr\u00e1k eset\u00e9ben a r\u00e1ksejtek CD155 proteint v\u00e1lasztanak ki, amelyek hozz\u00e1kapcsol\u00f3dnak a T-sejteken l\u00e9v\u0151 TIGIT receptorokhoz, ez\u00e1ltal elfojtj\u00e1k az immunrendszer term\u00e9szetes reakci\u00f3j\u00e1t.<\/p>\n\n\n\n

Az MIT kutat\u00f3i r\u00e1j\u00f6ttek, mik\u00e9nt lehetne feloldani ezt a korl\u00e1tot, \u00e9s beavatkozni a folyamatokba. A PD-1 checkpoint inhib\u00edtorokat TIGIT inhib\u00edtorral, valamint speci\u00e1lis, CD40 antitest agonist\u00e1val vegy\u00edtett\u00e9k, a kokt\u00e9lt pedig hasny\u00e1lmirigyr\u00e1kos egereken tesztelt\u00e9k.<\/p>\n\n\n\n

R\u00e1j\u00f6ttek, hogy a gy\u00f3gyszer-kombin\u00e1ci\u00f3 seg\u00edts\u00e9g\u00e9vel t\u00f6bb mint 50 sz\u00e1zal\u00e9kkal cs\u00f6kkenteni lehet a daganatok m\u00e9ret\u00e9t, m\u00edg az \u00e1llatok k\u00f6zel egynegyed\u00e9n\u00e9l v\u00e9g\u00e9rv\u00e9nyesen el is tudt\u00e1k t\u00fcntetni a tumorokat a szervezetb\u0151l.<\/p>\n\n\n\n

Egyel\u0151re teh\u00e1t biztat\u00f3nak \u00edg\u00e9rkezik a m\u00f3dszer, ez\u00e9rt nemsok\u00e1ra emberi \u00f6nk\u00e9nteseken is megkezd\u0151dhetnek a vizsg\u00e1latok, \u00e9s ha ezt az akad\u00e1lyt szint\u00e9n sikerrel veszik, akkor minden id\u0151k legbiztat\u00f3bb r\u00e1k elleni gy\u00f3gyszer\u00e9t dobhatj\u00e1k a k\u00f6zelj\u00f6v\u0151ben piacra.<\/p>\n\n\n\n

Forr\u00e1s: liner.hu<\/p>\n","protected":false},"excerpt":{"rendered":"

R\u00e1gcs\u00e1l\u00f3kon elv\u00e9gzett k\u00eds\u00e9rletek alapj\u00e1n az \u00faj, h\u00e1rom gy\u00f3gyszerb\u0151l \u00e1ll\u00f3 kokt\u00e9l k\u00e9pes legy\u0151zni a hasny\u00e1lmirigyr\u00e1kot, \u00e9s ha minden j\u00f3l alakul, akkor embereken is hasonl\u00f3 hat\u00e1s \u00e9rhet\u0151 el a ter\u00e1pi\u00e1val.<\/p>\n","protected":false},"author":4,"featured_media":66978,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15,41,594,49,592,598,39],"tags":[61947,10010],"class_list":["post-66977","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-a-nap-hirei","category-cikkek","category-egeszseg","category-hirek","category-tarsadalom","category-tudomany","category-vilag","tag-rak-elleni-gyogyszer","tag-tudomanyos-fejlesztes"],"_links":{"self":[{"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=\/wp\/v2\/posts\/66977","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=66977"}],"version-history":[{"count":0,"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=\/wp\/v2\/posts\/66977\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=\/wp\/v2\/media\/66978"}],"wp:attachment":[{"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=66977"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=66977"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/life.karpat.in.ua\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=66977"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}